Patients put at risk as crisis hits supplies of vital antibiotics, HRT and anti-depressants. / Vital antibiotics, hormone replacement therapy (HRT) and attention deficit hyperactivity disorder (ADHD) drugs are among those in desperately short supply this winter – with the NHS forced to pay over the odds to get drugs into Britain.

Businesses face 400 million extra customs declarations a year at a cost up as much as £20 billion under government plans.

Ex-cabinet minister Stephen Dorrell announces switch to Change UK, as Conservatives fall to a five-year polling low.