Patients put at risk as crisis hits supplies of vital antibiotics, HRT and anti-depressants. / Vital antibiotics, hormone replacement therapy (HRT) and attention deficit hyperactivity disorder (ADHD) drugs are among those in desperately short supply this winter – with the NHS forced to pay over the odds to get drugs into Britain.

Medicine shortages in the NHS are 'as bad as they've ever been' as a new report blames Brexit for the supply issues. / Antibiotics, hormone replacement therapy drugs, and ADHD medication are all in short supply this winter with NHS chiefs forced to pay gouged prices in order to fulfil demand.

Negotiations between the UK and Canada on a post-Brexit trade deal have broken down after nearly two years, following a row over beef and cheese. / Canada has been pushing for the UK to relax a ban on hormone-treated beef, which its producers say in effect shuts them out of the British market.

National Farmers’ Union president Minette Batters has taken a swipe at former prime minister Boris Johnson for adopting a “morally bankrupt” position during post-Brexit trade talks with the US.

Canada said no trade talks are in progress - despite Business Secretary Kemi Badenoch "explicitly" telling MPs discussions "have not broken down".